Funcţia în cadrul Proiectului: DIRECTOR DE PROIECT 1. Nume: LIEBSCHER 2. Prenume: JÜRGEN 3. Data şi locul naşterii: October 4, 1945, Freital, Germany 4. Cetăţenie: germana 5. Stare civilă: casatorit 6. Studii:
7. Experienţa profesională:
8. Titluri stiintifice: Profesor Doctor, conducator de doctorat 9. Limbi străine cunoscute: engleza 10. Brevete de invenţii, dacă există (in total 169): - RO-A/00401 – (15.07.2008), Preparation of magnetic nanostructures based on polypyrrole functionalized at N-atom by peptides - EP 90002395.3 – 2123 – (20.02.2009), Pharmaceutical compositions and their application în treatment of tumor diseases - WO 2007/096134 A1 (30. 8. 2007), Lipidated oligonucleotides - US 5 684 160 (4. 11. 1997), 3-Aminopyrroles, methods of their synthesis and application as pharmaceuticals - DD 299 273 (1992), Procedure for the extraction of silver from aqueous solutions
11. Lucrări publicate, dacă există (in total 232): - M. Loew, J. Kang, L. Dähne, R. Hendus-Altenburger, O. Kaczmarek, J. Liebscher, D. Huster, K. Ludwig, C. Böttcher, A. Herrmann, A. Arbuzova: Controlled Assembly of Vesicle-based Nanocontainers on Layer-by-Layer Particles via DNS Hybridisation“ Small 2009, 5, 320. - A. Nan, S. Karsten, I. Craciunescu, R. Turcu, L. Vekas, J. Liebscher: “New shells for magnetic nanoparticles based on polypyrrole functionalized with α-amino acids” ARKIVOC, 2008, 307. - Z. Yacob, J. Shah, J. Leistner, J. Liebscher: „(S)-Pyrrolidin-2-ylmethyl-1,2,3-triazolium salts Ionic-Liquid-Supported Organocatalysts for Enantioselective Michael Addition to ß-Nitrostyrenes”, Synlett 2008, 2342. - J. Shah, H. Blumenthal, Z. Yacob, J. Liebscher: „Proline catalyzed asymmetric aldol reactions în guanidine-derived ionic liquids“ Adv. Synth. Catal., 2008, 350, 1267. -A. Kurz, A. Bunge, A.-K. Windeck, M. Rost, W. Flasche, A. Arbuzova, D. Strohbach, S. Müller, J. Liebscher, D. Huster, A. Herrmann: „Lipid-Anchored Oligonucleotides for Stable Double Helix Formation în Distinct Membrane Domains” Angew.Chem. 2006, 118, 4550. 12. Membru al asociaţiilor profesionale: Societatea Germana de Chimie, Societatea Internationala de Chimia Heterociclurilor (membru în comitetul consultativ), Societatea Liebig, Societatea Profesorilor din Germania.
13. Specializări şi calificări: Sinteza organica cu o vasta intindere în diferite domenii si o cuprinzatoare experienta dobandita de-a lungul multor ani, nanobiotehnologie, materiale, chimie bioorganica, cataliza, lichide ionice, sinteza asimetrica.
14. Experienţa acumulată (inclusiv managerială) în alte programe/proiecte naţionale/internaţionale:
15. Lista celor mai importante publicatii/brevete: - Hu Peng, Soundarapandian Vijayakumar, Cordelia Schiene-Fischer, Hui Li, Jeffrey M. Purkerson, Miroslav Malesevic, Jürgen Liebscher, Qais As-Awqati, George J. Schwartz: „Sectreted Cyclophilin A, a Peptidylprolyl cis-tran Isomerase, Mediates Matrix Assembly of Hensin, a Protein Implicated în Epithelial Differentiation” J. Biol. Chem., 2009, 284, 6465. - J. Shah, J. Liebscher: „Synthesis of Chiral α-Amino Ester Derived Pentasubstituted Guanidines and Hexasubstituted Guanidinium Salts as Potential Ionic Liquids”, Synthesis, 2008, 917. - O. Kaczmarek, N. Brodersen, A. Bunge, L. Löser, D. Huster, A. Herrmann, A. Arbuzova, J. Liebscher: „Synthesis of Nucleosides with 2´-Fixed Lipid Anchors and Their Behavior în Phospholipid Membranes”, Eur. J. Org. Chem.,2008, 1917. - J. Shah, J. Liebscher: „Synthesis of Chiral α-Amino Ester Derived Pentasubstituted Guanidines and Hexasubstituted Guanidinium Salts as Potential Ionic Liquids”, Synthesis, 2008, 917. - S. Hanelt, J. Liebscher: „A Novel and Versatile Access to Task-Specific Ionic Liquids Based on 1,2,3-Triazolium Salts”, Synlett, 2008, 1058. - H.-J. Hamann, A. Bunge, J. Liebscher: „Reaction of Epoxyketones with Hydrogen Peroxide - Ethane-1,1-dihydroperoxid as a Surprisingly Stable Product“, Chemistry Eur. J. 2008, 14, 6849. - R. Turcu, A. Nan, I. Craciunescu, J. Liebscher, O. Pana, D. Bica, L.Vekas, C. Mijangos: “Comparative study of hybrid nanostructures of polymer-magnetic nanoparticles”, Journal of Optoelectronics and Advanced Materials, vol. 10, No. 9, 2008, 2237. - A. Nan, I. Craciunescu, R. Turcu, D. Reichert, J. Liebscher: „Synthesis and characterization of new functionalised pyrrole copolymers”, Journal of Optoelectronics and Advanced Materials, 2008, 10, 2265. - A. Nan, I. Craciunescu, A. Bende, R. Turcu, D. Reichert, J. Liebscher: „Synthesis and Structure Investigation of Functionalized Polypyrrole Copolymers”, Journal of Nanostructured Polymers and Nanocomposites, 2008, 4, 3. - A. Bunge, A. Kurz, A.-K. Windeck, T. Korte, W. Flasche, J. Liebscher, A. Herrmann, D. Huster: „Lipophilic Oligonucleotides Spontaneously Insert into Lipid Membranes, Bind Complementary DNA Strands, and Sequester into Lipid Disordered Domains”, Langmuir 2007, 23, 4455. - M. Sieber, M. Karanik, C. Brandt, C. Blex, M. Podtschaske, F. Erdmann, R. Rost, E. Serfling, J. Liebscher, M. Pätzel, A. Radbruch, G. Fischer, R. Baumgrass: “Inhibition of calcineurin-NFAT signaling by the pyrazolopyrimidine compound NCI3”, Eur. J. Immun. 2007, 37, 2617. - N. Brodersen, J. Li,O. Kaczmarek, A. Bunge, L. Löser, D. Huster, A. Herrmann, J. Liebscher: “Nucleosides with 5´-Fixed Lipid Groups – Synthesis and Anchoring în Lipid Membranes”, Eur. J. Org. Chem. 2007, 6060. - V. Karunakaran, T. Senyushkine, G. Saroja, J. Liebscher, N. P. Ernsting: “2-Amino-7-Nitro-Fluorenes în Neat and Mixed Solvents – Optical Band Shapes and Solvatochromism”, J. Phys. Chem. A, 2007, 111, 10944. - L. Yin, J. Liebscher: ”Carbon-Carbon Coupling Reactions Catalyzed by Heterogeneous Palladium Catalysts”, Chem. Rev. 2007, 107, 133. - H.-J. Hamann, A. Wlosnewski, T. Greco, J. Liebscher: „Novel Hydroperoxydioxolanes and –dioxanes by Hydroperoxide-Rearrangement and Ozonolysis”, Eur. J. Org. Chem. 2006, 2174. - H. Faltz, C. Bender, J.Liebscher: “Synthesis of Optically Active Condensed Tetrahydropyridines from a-Amino Esters”, Synthesis 2006, 2907. - L. Yin, J. Liebscher: “w-Functionalized 3-Alkynylpyrazolo[1,5-a]pyrimidines by Sonogashira Coupling”, Synthesis 2005, 131. - G. Saroja, Z. Pingzhu, L. Perez-Lustres, N. P. Ernsting, J. Liebscher: „Donor-Acceptor Substituted Fluorenes for Femtosecond Polar Solvation Studies: Synthesis of Alkylated Aminofluorenes by Palladium-Catalyzed Substitution at Halofluorenes“, J. Org, Chem. 2004, 69, 987. - W. Flasche, C. Cismas, A. Herrmann, J. Liebscher: „Lipophilic Nucelosides by Sonogashira Coupling”, Synthesis 2004, 2335. - L. Yin, J. Liebscher: ”Convenient Synthesis of Substituted 3-Vinyl-pyrazolo[1, 5-a] pyrimidines via Heck Cross-coupling Reaction”, Synthesis 2004, 2329. - H. Faltz, C. Bender, B. Wöhrl, K. Vogel-Bachmayr, U. Hübscher, K. Ramadan, J. Liebscher: “Double-Cyclization of Di(a-hetarylmethyl)amino Esters to Optically Active Bridged N-Heterocycles of HIV Inhibiting Activity”, Eur. J. Org. Chem. 2004, 3484. - H. A. Scheidt, W. Flasche, C. Cismas, A. Herrmann, J. Liebscher, D. Huster: „Design and Application of Lipophilic Nucleosides as Building Blocks to Obtain Highly Functional Biological Surfaces”, J. Phys. Chem. B 2004, 108, 16279. -V. Nair, S. M. Nair, S. Mathai, J. Liebscher, B. Ziemer, K. Narsimulu: “The Rh(II) catalyzed reaction of diethyl diazomalonate with thietanes: a facile synthesis of tetrahydrothiphene derivatives via sulfonium ylides”, Tetrahedron Lett. 2004, 45, 5759. - S. Swaleh, J. Liebscher: "New Strategy for the Synthesis of Iminoglycitols from Amino Acids", J. Org. Chem. 2002, 67, 3184. - D. Schley, A. Radspieler, G. Christoph, J. Liebscher: "a-Arylation of 2-Arylacetates and Benzofuran-2-one with Tricarbonyl(fluoroarene)chromium Complexes", Eur. J. Org. Chem. 2002, 369. - J. Hübner, J. Liebscher, M. Pätzel: “Optically Active Nitroalkenes – Synthesis, Addition Reactions and Transformation into Amino Acids“,Tetrahedron 2002, 58, 10485. - A. Radspieler, J. Liebscher:"Total Synthesis of Phorbazole C”, Tetrahedron 2001, 57, 4867. - S. Jin, P. Wessig, J. Liebscher: "Intermolecular and Intramolecular Diels-Alder Cycloadditions of 3-Ylidenepiperazine-2,5-diones and 5-Acyloxy-2(1H)-pyrazinones", J. Org. Chem. 2001, 66, 3984. - O. Surygina, M. Ehwald, J. Liebscher: "Enantiomerically Pure Dihydroimidazoisoquinolinones by Reaction of Isoquinoline with amino acid fluorides", Tetrahedron Lett. 2000, 41, 5479. - S. Jin, P. Wessig, J. Liebscher: "Unusual C=C Bond Migration în 3-Ylidene-2,5-piperazindiones", Eur. J. Org. Chem. 2000, 1993. - J. Liebscher, S. Jin, A. Otto, K. Woydowski: "Synthetic Application of Chiral Pool Derived Heterocycles", J. Heterocycl. Chem. 2000, 37, 509. - DE 196 53 355 A1 (25. 6. 1998), New anticonvulsive aminoimidazoles and methods of their synthesis - US-Pat. 5 414 082 (1995), Procedure for the synthesis of 1-unsubstituted 3-aminopyrroles Declar pe proprie răspundere că datele prezentate sunt în conformitate cu realitatea. Data completării: 06.05.2010 |
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