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NANOSTRUCTURED BIOCOMPATIBLE SYSTEMS BASED ON MAGNETIC NANOPARTICLES AND STIMULI RESPONSIVE POLYMERS |
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Contract nr: 71-068 / 2007
Contact: Dr. Rodica Turcu |
Results
Stage I StageII StageIII StageIV Stage IV
I. Synthesis of nanostructures based on magnetite and biocompatible block copolymers
Three types of core-shell magnetic nanostructures based on biocompatible copolymers were obtained. The copolymers are polycaprolactone – co –polylactic acid, poly(N-isopropylamide ) – co – poly(N-acryloilsuccinimide), poly(N- isopropylamide) – co – poly(propargylacrilate). The synthesis methods are innovative, in the literature there aren’t reports of these magnetic structures. Core-shell magnetic nanostructures based on polycaprolactone and polylactic acid, are a combination between two polymers with different properties in the same material. Polycaprolactone present a very high permeability and interesting thermal properties. Polylactic acid presents a high degree of hydrophilicity and bioresorbant properties. Both polymers are highly biodegradable, the resulted compounds after degradation can be easily eliminated by the organism. The nanocomposites based on poly(N- isopropylamide) and poly(N-acryloilsuccinimide) are a combination between a smart polymer which is thermal responsive, with critical temperature (LCST) 30–32°C, and a polymer with a high functionalization potential trough succinimide group.
II. Characterization of smart materials with core-shell structure based on magnetic nanoparticles and biocompatible polymers FTIR spectra show the characteristic absorption bands of magnetite and the copolymers. The shift of the specific absorption band of magnetite covered with copolymers, from the band of bare magnetite, proves the formation of core-shell nanostructure. An absorption band shift is observed also for the copolymer that covers the nanoparticle compared to the bare copolymer.
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